Bringing
LEMS To Light
LEMS Aware was created to help physicians recognize, diagnose, and treat Lambert-Eaton myasthenic syndrome (LEMS), a rare and frequently unrecognized, neuromuscular disorder.1
Scroll
Information to help you change lives.
LEMS Aware delivers relevant content, resources, and expert insights to assist physicians who may encounter, or be treating, patients with LEMS. Wherever your patient is on their journey to feeling better—searching for a diagnosis or the right treatment—this site can help you guide them to that next milestone.
On the basis of our experience with the six patients, three of whom were found to have intrathoracic malignant lesions…it is interesting to speculate that the neuromuscular syndrome described may in some way be related to the malignancy.
Should this syndrome prove to be of some clinical importance, electromyography and stimulation of nerves must be given the greatest credit. Without these techniques, the syndrome would have been confused with myasthenia gravis and its significance would have continued to elude us.
—Eaton and Lambert, 19572
What is LEMS?
Lambert-Eaton myasthenic syndrome, also known as LEMS, is an autoimmune disorder that affects neuromuscular transmission. It is named for Dr. Edward Lambert and Dr. Lee Eaton—the two Mayo Clinic neurologists who first described the clinical and electrophysiological characteristics of the syndrome in 1957.3
LEMS typically begins with lower-limb muscle weakness and general fatigue, making it difficult for patients to rise from a seated position, climb stairs, or even walk.3 LEMS can also start within or progress to the muscles of the upper arms and shoulders4, making self-care and independence difficult.3 Many patients also experience autonomic symptoms, such as dry mouth and constipation.3,4 More detailed information about LEMS and its symptoms is available in the next section.
Consult with a representative
Whether you’re familiar with LEMS or just learning about it, LEMS Aware has representatives available to answer any questions you may have.
LEMS And Pregnancy
READY TO LEARN MORE ABOUT LEMS?
LEMS differential diagnosis
There are several neuromuscular conditions that share clinical symptoms with LEMS and can lead to delays in diagnosis and appropriate treatment.1,4 Discover key clues that can help expedite a diagnosis for your patients.
Screening for cancer
LEMS is caused by pathogenic autoantibodies to voltage-gated calcium channels in the neuromuscular junction. In up to 60% of cases, these autoantibodies are produced in response to an underlying tumor.4 Learn more about the connection between cancer and LEMS and how a LEMS diagnosis may help uncover a hidden malignancy.
Patient support resources
Your patients can play an important role in communicating their symptoms and managing their treatment. Share these helpful tools and resources with your patients.